A narrative review of the surgical management of Paget-Schroetter syndrome: case series and long-term follow-up

Mohamad Bashir, Sven ZCP Tan, Matti Jubouri, Ghali Salahia, Richard J. Whiston, Richard D. White, Damian M. Bailey, Ian M. Williams

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Background and Objective: Paget-Schroetter syndrome (PSS) is an uncommon disorder which causes thrombosis of the subclavian vein (SV). This is due to compression of the SV by the surrounding anatomical structures. The optimal management of PSS remains subject to debate, with endovascular intervention and open surgical decompression being favoured current options. This review article evaluates both approaches to the management of PSS, while also presenting a case series with long-term follow-up of patients that underwent open surgical intervention for PSS.

Methods: The clinical outcomes of PSS patients undergoing different 4 surgical approaches to perform surgical decompression are included. A literature review, across publications from PubMed, Embase, and Web of Science, was conducted with specific criteria to facilitate evaluation of both open surgical and endovascular approaches to the management of PSS.

Key Content and Findings: Evaluation of data from the included case series and available literature suggests that endovascular thrombolytic devices offer better clinical results, however, SV decompression is still required for successful resolution.

Conclusions: An approach to PSS encompassing endovascular intervention followed by surgical anatomical decompression may provide optimal outcomes as both intrinsic lesions and extrinsic compression of the SV is treated. However, further prospective investigation into this field is warranted.
Original languageEnglish
Article number99534
Pages (from-to)744-755
Number of pages12
JournalCardiovascular Diagnosis and Therapy
Issue number5
Publication statusPublished - 4 Aug 2022


  • Paget-Schroetter Syndrome (PSS)
  • surgical
  • endovascular


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