Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia

Richard A E Edden, Ashley D Harris, Kevin Murphy, C John Evans, Neeraj Saxena, Judith E Hall, Damian M Bailey, Richard G Wise

Research output: Contribution to journalArticlepeer-review


PURPOSE: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges.

MATERIALS AND METHODS: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O(2)), hypoxic (12% O(2)), and hyperoxic (40% O(2)) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume.

RESULTS: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia.

CONCLUSION: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.

Original languageEnglish
Pages (from-to)320-5
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Issue number2
Publication statusPublished - 1 Aug 2010


  • mrs
  • lactate
  • hypoxia
  • mega press
  • hyperoxia


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