Redox Regulation of Post-Prandial Vascular Endothelial Dysfunction

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Tyldum et al. (1) elegantly demonstrated that an acute bout of high-intensity interval exercise (HIE) provides superior prophylaxis against post-prandial vascular endothelial dysfunction compared with an isocaloric bout of continuous moderate-intensity exercise. The post-prandial maintenance of brachial artery flowmediated vasodilation was attributed to an enhanced mobilization of antioxidants into the systemic circulation, which was shown to be exercise-intensity dependent. The authors speculated that by neutralizing lipemia-induced oxidative stress, HIE preserved endothelial function subsequent to an increase in vascular nitric oxide (NO) bioavailability. Given the limited assessment of free radical metabolism, I would like to raise some additional points for consideration and indeed proffer an alternative interpretation at least for their metabolic findings. ...
Original languageEnglish
JournalJournal of the American College of Cardiology
Publication statusPublished - 16 Jan 2010


  • post-prandial vascular


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