Simulation of gas exchange and pulmonary blood flow using a water- displacement model lung

E.M. Williams

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The transport of oxygen by blood to the tissues begins at the lungs. Here fresh inspired oxygen diffuses into the blood while metabolically produced carbon dioxide diffuses out of the blood. To perform this simple function the lungs require a large surface area. This is achieved by the lungs having a complex sponge-like structure, consisting of millions of microscopic gas-exchanging units each with their own blood supply. In the healthy lung these myriads of units can be treated as one large unit. This simplification has allowed the development of numerous mathematical models describing lung ventilation, gas exchange and perfusion. The simpler mathematical models consist of just three compartments: a dead space, Vd (the ventilated but non gas-exchanging airways of the lungs), an alveolar volume, Va (the combined volume of the gas exchange units) and a gas-exchanging blood volume, Qp (pulmonary blood flow). Many of these mathematical models make further simplifications and assume that the ventilation of the lungs is continuous rather than tidal.
Original languageEnglish
Title of host publicationOxygen Transport to Tissue XVII
EditorsC. Ince, J. Kesecioglu, L. Telci, K. Akpir
Number of pages8
ISBN (Electronic)978-1-4613-0333-6
ISBN (Print)978-1-4613-8002-3
Publication statusPublished - 24 Nov 1996
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • animal experiment
  • animal model
  • blood flowmetry
  • conference paper
  • controlled study
  • gas mixing
  • lung alveolus cell
  • lung blood flow
  • lung dead space
  • lung gas exchange
  • lung perfusion
  • nonhuman
  • oxygen diffusion
  • oxygen transport
  • priority journal
  • rat
  • respiratory function
  • simulation


Dive into the research topics of 'Simulation of gas exchange and pulmonary blood flow using a water- displacement model lung'. Together they form a unique fingerprint.

Cite this