Zinc barbier reaction of propargyl halides in water

Lothar W. Bieber, Margarete F. da Silva, Rosenildo Da Costa, Lilia O.S. Silva

Research output: Contribution to journalArticlepeer-review


The reaction of propargyl halides and carbonyl compounds with zinc powder proceeds in concentrated aqueous salt solutions affording with high selectivity homopropargylic alcohols. Preparatively useful yields are obtained with aromatic and aliphatic aldehydes. Ketones and 2-hydroxybenzaldehydes react partially. A surface process of two SET is discussed.

Carbonyl compounds and propargyl halides react with zinc in aqueous solutions to give mainly homopropargylic alcohols
Original languageEnglish
Pages (from-to)3655-3658
JournalTetrahedron Letters
Issue number22
Publication statusPublished - 1998


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